KJ Ceramics 31

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Detailed Program

Paper Number : BI-I02

Time Frame : 15:00~15:25

Presentation Date : Thurse day, 27, November

Session Name : Biomaterials

Session Chair 1# : H.S Yoon

Session Chair 2# : K.Uetsuki

Development and evaluation of novel hybrid systems of ceramic and polymer for bone tissue regeneration

Byong Taek LEE

Soonchunhyang University

Bone tissue regeneration using biomaterials based scaffolds is a very much complex process where both physical stability and biological processes should be considered. Traditional synthetic porous scaffolds, fabricated with either metals or polymers or ceramics, were not able to ensure native structure, strength, degradation of the scaffold and osteoblastic activates simultaneously. Thus strategies for bone tissue engineering and regeneration should rely on bioactive scaffolds to mimic the natural extracellular matrix and act as templates onto which cells attach, multiply, migrate and. Our particular interest is composites and hybrid biomaterials based on selective combinations of biodegradable polymers and bioactive ceramic materials. Herein, I am going to present some novel design of hybrid scaffolds and evaluation of their in vitro and in vivo potentiality in bone regeneration. We focus specifically on hydroxyapatite (HA), biphasic calcium phosphate (BCP) and bioactive glass (BG) in combination with biodegradable gelatin, hyaluronic acid, collagen and decellularized extracelluar matrix. Among our several own hybrid systems, BCP scaffold with gelatin-hyaluronic acid hydrogel; three layered spongy scaffold BCP-Bioglass-Gelatin; silicon doped BCP micro channeled granular bone substitute with collagen and BMP-2; BMP-2 and VGEF loaded BCP-Cellulose composite scaffold. These topics include 3D scaffold design and fabrication, vast physical characterizations, in vitro responses through osteoblast attachment, proliferation and osteogenesis and in vivo performance evaluation by implanting the scaffold in non-union defects segmental. We conclude with a perspective on the future application of novel designed ceramic-polymer hybrid scaffolds for regeneration of hard tissue.
Fig.1

Figure 1 Masson trichrome staining of bone regeneration on the microchannels after 1 week- infiltration of fibroblast cells and osteoblast cells (a). Bone regeneration after 4 weeks- vascularization surrounded by dense collagen to form lamellar bone formation in longitudinal direction (b).

Acknowledgements :

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