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Detailed Program
Paper Number : BI-O01
Time Frame : 13:55~14:07
Presentation Date : Thurse day, 27, November
Session Name : Biomaterials
Session Chair 1# : Byong Taek Lee
Session Chair 2# : Il Young Kim
The Relevance of Biological Nutrients to the Prevention and Treatment of Osteoporosis
Garima TRIPATHI
KIMS
Osteoporosis is a worldwide disease with an excessive prevalence in humans. A number of commercial biomaterials are presently used to treat osteoporotic bone fractures, but most of these have not been precisely designed for the purpose. Calcium Phosphate (CaP) compounds are well accepted by living organism with time, newly formed bone grows onto/into calcium phosphate ceramics and finally leads to stable osteointegration. For the purpose, in the present paper, a novel room temperature process has been reported to produce a 3D porous calcium phosphate scaffold with drug load/release efficacy for use in the treatment of osteoporosis. The developed technique is a combination of a paste extruding deposition (PED) system and cement chemistry. Cementation process has been chosen as opposed to the typical sintering process in ceramic scaffold fabrication which lead to unexpected crystallization, low biodegradability and bioactivity, unstable mechanical properties, high cost, and suppressed biological performance. Flavonoids, commonly known as a nutrient, have been selected as a model drug; it was loaded onto CaP powder to introduce homogeneous distribution in the scaffold. The cytocompatibility of the developed drug loaded scaffolds was validated through cell culture experiment with different types of bone cells which are responsible for bone formation as well as bone resorption. The results showed that the cell proliferation behavior was enhanced on flavonoid loaded 3D CaP scaffold in case of bone forming osteoblast type cells. On the other hand there was decrease in the proliferation rate in case of bone resorbing multinucleated osteoclast cells. In summary it can be reported that preliminary experiments can conclude that the chosen biomolecule can be an emergent candidate for the treatment of osteoporosis.
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