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Detailed Program
Paper Number : BI-O03
Time Frame : 14:19~14:31
Presentation Date : Thurse day, 27, November
Session Name : Biomaterials
Session Chair 1# : Byong Taek Lee
Session Chair 2# : Il Young Kim
Fabrication of Core shell scaffolds by simultaneous extrusion of ceramic and hydrogel for bone tissue engineering
Naren RAJA
Korea University of Science and Technology
An ideal scaffold for bone tissue regeneration should have bone-mimicking features such as high porosity and pore structure, biodegradability, bioactivity, biocompatibility and sufficient mechanical properties. Clinically favored materials for bone scaffold are based on bioceramics because of the chemical similarity of these materials to the mineral phase of bone. Scaffolds can be fabricated in a variety of ways including particulate leaching, gas foaming, phase separation, freeze drying, and 3D printing. Regardless of fabrication processes, heterogeneous cell distribution and in-growth into the scaffolds still remain as significant shortcomings in bone tissue engineering because cell seeding is normally performed by pipetting cells after the fabrication of the 3D scaffolds. The purpose of this study is to overcome this problem. Paste extruding deposition process, which is one of 3D printing process, was applied to obtain ideal structural conditions of scaffold and calcium phosphates was selected to satisfy biocompatibility and mechanical properties as well. We designed ceramic-hydrogel core-shell structured scaffold to this end and developed novel process using our original room temperature fabrication process of 3D ceramic scaffolds [1]. By precise control over the system using computer-aided design data we could fabricate calcium deficient hydroxyapatite-alginate core shell structured scaffolds. By using this construction we could not only achieve homogeneous cell distribution throughout the 3D scaffolds but also obtain favorable mechanical properties as bone scaffold. The dimensions of the scaffolds in terms of compressive strength and modulus increased with increasing the size of core. Because the whole process is carried out in a gentle condition for the cells, the incorporated cells in the shell were well distributed and alive throughout the 3D scaffold for the entire cultured period (7 days).
References
[1] Lee, J., Farag, M. M., Park, E. K., Lim, J., & Yun, H. S. (2014). A simultaneous process of 3D magnesium phosphate scaffold fabrication and bioactive substance loading for hard tissue regeneration. Materials Science and Engineering: C, 36, 252-260.
Acknowledgements : This work was supported by the Mid-Career Researcher Program, through an NRF grant funded by The Korea Ministry of Education, Science, and Technology (MEST) (Number 2011-0017572).